David Hansel

Oct 16, 2024 | biorxiv.org | Jagruti J. Pattadkal |Ronan O'Shea |David Hansel |Thibaud Taillefumier

AbstractCortical neurons are characterized by their variable spiking patterns. We challenge prevalent theories for the origin of spiking variability. We examine the specific hypothesis that cortical synchrony drives spiking variability in vivo. Using dynamic clamp, we demonstrate that intrinsic neuronal properties do not contribute substantially to spiking variability, but rather spiking variability emerges from weakly synchronous network drive.