David Howard

Jan 14, 2025 | nature.com | Lachlan Gilchrist |Thomas P. Spargo |Rebecca Green |David Howard |Jackson G. Thorp |Brett N. Adey | +25 more

AbstractDepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship.

Jun 12, 2024 | nature.com | Joeri J. Meijsen |Kejia Hu |Morten Krebs |Georgios Athanasiadis |Sarah Washbrook |Richard Zetterberg | +14 more

AbstractMental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders.

Feb 7, 2023 | nature.com | Patrícia Silveira |David Howard

AbstractThere are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide association studies (GWAS) adjust for sex differences, to date, no studies seek to identify sex-specific markers and pathways.