David Howard

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Articles

Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease - Nature Mental Health

Jan 14, 2025 | nature.com | Lachlan Gilchrist |Thomas P. Spargo |Rebecca Green |David Howard |Jackson G. Thorp |Brett N. Adey | +25 more

AbstractDepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship.
Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians | Nature Communications

Jun 12, 2024 | nature.com | Joeri J. Meijsen |Kejia Hu |Morten Krebs |Georgios Athanasiadis |Sarah Washbrook |Richard Zetterberg | +14 more

AbstractMental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders.

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