Articles
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Dec 12, 2024 |
nbcnewyork.com | David L
About six months ago, Donald Trump was sitting in a courtroom in lower Manhattan listening to a jury make him the first former president convicted of a crime. On Thursday, he will ring the opening bell at the New York Stock Exchange just blocks from that courthouse and as he was recognized by Time magazine as its person of the year.
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Nov 18, 2024 |
nbcnewyork.com | David L
Spirit Airlines said Monday that it has filed for bankruptcy protection and will attempt to reboot as it struggles to recover from the pandemic-caused swoon in travel and a failed attempt to sell the airline to JetBlue. Spirit, the biggest U.S. budget airline, has lost more than $2.5 billion since the start of 2020 and faces looming debt payments totaling more than $1 billion over the next year.
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Sep 16, 2024 |
nbcnewyork.com | David L
Some public figures are honored with namesake buildings or monuments. Veteran broadcaster Connie Chung has a strain of marijuana and hundreds of Asian American women as legacies. Chung was contacted five years ago by a fellow journalist, Connie Wang, whose Chinese immigrant parents gave her the chance as a preschooler to pick an Americanized first name. She thought of Connie, after the pretty woman she saw on TV, and also suggested some random cartoon characters. Her parents chose wisely.
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Aug 5, 2024 |
molecular-cancer.biomedcentral.com | David L |Peter MacCallum
We thank Silvia Stoev, Rachel Hancock, Kathy Barber, Scott Wood and Conrad Leonard for technical assistance. We thank Amanda Spurdle and Michael Parsons (QIMR Berghofer) for their advice regarding BRCA1 SNPs potentially affecting splicing. We thank Clovis Oncology for providing rucaparib for in vivo experiments; Violeta Serra and Judith Balmana for the PDX models #124 and #196; Elgene Lim for #1126, Scott H.
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Aug 4, 2024 |
link.springer.com | David L |Peter MacCallum
AbstractPARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Multiple resistance mechanisms have been described, including secondary mutations that restore the HR gene reading frame.
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