David Lee

1 month ago | biorxiv.org | Saurabh Sharma |David Lee |Surjendu Maity |Prabhjeet Singh

AbstractGlioblastoma Multiforme (GBM) represents a significant clinical challenge amongst central nervous system (CNS) tumors, with a dismal mean survival rate of less than 8 months, a statistic that has remained largely unchanged for decades (National Brain Society, 2022).

Jun 25, 2024 | biorxiv.org | Xinru Wang |Jordi Guillem-Marti |Saurav Kumar |David Lee

AbstractIntegrin α5β1 is crucial for cell attachment and migration in development and tissue regeneration, and α5β1 binding proteins could have considerable utility in regenerative medicine and next-generation therapeutics. We use computational protein design to create de novo α5β1-specific modulating miniprotein binders, called NeoNectins, that bind to and stabilize the open state of α5β1.