David Miklos

2 months ago | nature.com | George Duran |David Miklos |Surbhi Sidana |Mia Carleton |Alisha M. Maltos

AbstractDespite advances in treatments, multiple myeloma (MM) remains an incurable cancer where relapse is common. We developed a circulating tumor DNA (ctDNA) approach in order to characterize tumor genomics, monitor treatment response, and detect early relapse in MM. By sequencing 412 specimens from 64 patients with newly diagnosed or relapsed/refractory disease, we demonstrate the correlation between ctDNA and key clinical biomarkers, as well as patient outcomes.

Dec 17, 2023 | nature.com | Philip L McCarthy |Amin M. Alousi |David Miklos |Ran Reshef |Richard T Maziarz |John Levine

AbstractIdentifying plasma biomarkers early after allo-HCT may become crucial to prevent and treat severe aGvHD. We utilized samples from 203 allo-HCT patients selected from the Blood & Marrow Transplant Clinical Trials Network (BMT CTN) to identify new biomarker models to predict aGvHD and overall mortality. Two new biomarkers (Gal-3 and LAG-3), and previously identified biomarkers (ST2/IL33R, IL6, Reg3A, PD-1, TIM-3, TNFR1) were screened.

Aug 4, 2023 | gatopardo.com | David Miklos

Tiempo de lectura: 9 minutosI.

Aug 4, 2023 | gatopardo.com | David Miklos

Sinéad (1966-2023) Sinéad O’Connor, rara debutante rapada, hechizó los ojos y los oídos del mundo con la incomparable “Nothing Compares 2 U”. Luego rompería una foto del papa en televisión. ¿Su carrera musical se hizo pedazos entre sus manos, como aquel retrato de Juan Pablo II? David Miklos, su contemporáneo, recuerda plenamente a la cantante y sus aspiraciones, que iban muchísimo más allá de la música.