de Borst

Oct 24, 2024 | karger.com | de Borst

Keywords: Chronic kidney disease-mineral and bone disorder, Parathyroid hormone, Kidney function, Calcifediol Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by skeletal and cardiovascular abnormalities, including CKD-associated osteoporosis and vascular calcification. It is more likely to occur with more advanced CKD and has been linked with a reduced quality of life and premature mortality.

Mar 28, 2024 | arxiv.org | Van der Linden |de Borst

[Submitted on 28 Mar 2024] Title:A multi-step calibration strategy for reliable parameter determination of salt rock mechanics constitutive models View a PDF of the paper titled A multi-step calibration strategy for reliable parameter determination of salt rock mechanics constitutive models, by Herm\'inio T.

Nov 20, 2023 | academic.oup.com | de Borst

Patients with ADPKD have disproportionately high levels of fibroblast growth factor-23 (FGF-23) for their CKD-stage with only a subgroup that develops kidney phosphate wasting. We assessed factors associated with phosphate wasting and hypothesize that it identifies patients with more severe disease and predicts disease progression. We included 604 patients with ADPKD from a multi-center prospective observational (DIPAK) cohort in 4 university medical centers in the Netherlands.

Oct 9, 2023 | academic.oup.com | de Borst |Alexander H. J

Dietary potassium (K+) has emerged as a modifiable factor for cardiovascular and kidney health in the general population, but its role in people with chronic kidney disease (CKD) is unclear. Here, we hypothesize that CKD increases the susceptibility to negative effects of low and high K+ diets.

Oct 9, 2023 | academic.oup.com | de Borst |Alexander H. J

In the general population dietary potassium (K+) intake is ∼54 mmol/day [1] which is below the recommended intake of 90–120 mmol/day [2, 3]. Low dietary K+ intake is associated with salt-sensitive hypertension [4] and with a higher incidence of stroke [5], chronic kidney disease (CKD) [6] and mortality [7]. Increasing K+ intake through K+ supplementation or salt substitution decreases blood pressure and improves cardiovascular outcomes [5, 8].