Denise G. Lanza

Sep 14, 2023 | nature.com | Sung Yun Jung |Nadia Agha |Christopher Ward |Denise G. Lanza |Pumin Zhang |George G. Rodney | +1 more

AbstractHere we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (Esd), Cardiomyopathy-Associated Protein 5 (Cmya5), and Fibronectin Type III and SPRY Domain Containing 2 (Fsd2) in cardiac and skeletal muscle.