Dennis J. Hsu

May 16, 2024 | cell.com | Dennis J. Hsu |Sohail F. Tavazoie

Yang, Pataskar, et al. investigated the impact of arginine shortage on aberrant mRNA translation in cancer. They report the enrichment of arginine-to-cysteine substitutants in human lung cancer, link it to a tRNA misalignment mechanism, and connect it to KEAP1 pathway mutations and platinum resistance.

Sep 7, 2023 | mdpi.com | Akshit Chitkara |Muhammad Arsalan Bakhtiar |Ibrahim Halil Sahin |Ibrahim Şahin |Dennis J. Hsu

3. Results 3.1. Study CharacteristicsTwo of the six trials selected evaluated trastuzumab deruxtecan, and one evaluated trastuzumab plus lapatinib. One trial evaluated pertuzumab plus trastuzumab emtansine, while one evaluated trastuzumab plus tucatinib, and one evaluated trastuzumab plus pyrotinib (Table 2). Regarding prior lines of treatment, the median number of prior lines was two and three in two trials and four and five in one trial each.