Departamento de Patologia

Nov 29, 2024 | jneuroinflammation.biomedcentral.com | Departamento de Patologia |Facultad de Medicina |Universidad Valencia

We analyzed the time-course of the changes of IL-17 in blood induced by eating the ammonia-containing diet. This diet induced a sustained increase of ammonia levels in blood (Fig. 2A). Hyperammonemia induced a transient increase in the plasma levels of IL-17 (Fig. 2B) which was significantly increased at 3 days of hyperammonemia but decreased to normal levels, not different from control rats at 7 days of hyperammonemia.

Apr 26, 2024 | link.springer.com | Departamento de Patologia |Facultad de Medicina |Universidad Valencia

AbstractPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordination in hyperammonemic rats is due to increased GABAergic neurotransmission in cerebellum, induced by neuroinflammation, which enhances TNFα-TNFR1-S1PR2-CCL2-BDNF-TrkB pathway activation. The initial events by which hyperammonemia triggers activation of this pathway remain unclear.