Articles

  • 2 weeks ago | chemistryworld.com | Derek Lowe

    Ignoring physiological differences between the sexes is indefensibleBased on my own experiences in drug discovery, I think there are two (nearly opposite) large-scale mistakes that can be made relating to women and their treatment. Source: © Anchiy/Getty Images One is the historical error of treating the entire female side of the human species as if it weren’t there, or can be easily approximated as slightly different-shaped males.

  • 1 month ago | chemistryworld.com | Derek Lowe

    To codify and predict ever more complex phenomena is one of science’s great drivers Source: © Daniel Liévano/Ikon Images There are a lot of reasons why people are motivated to do scientific research, with sheer curiosity about the natural world being near the top of the list. But there’s another one that I think doesn’t get enough attention: the desire to believe that there really are truths and rules. To someone outside the field, that might sound a bit perverse.

  • 2 months ago | chemistryworld.com | Derek Lowe

    Overheard recently in a seminar room near you… Source: © Wouter Tulp/Ikon Images Let me start with a few comments about our medicinal chemistry group that probably apply equally to all of the therapeutic areas below. I have been told at various times over the years that computational methods were becoming so powerful that they were going to lead us directly to drugs. Then I was told that making uncountable zillions of near-random compounds was the way forward.

  • 2 months ago | science.org | Derek Lowe

    The latest addition to the long list of chemicals that I never hope to encounter takes us back to the wonderful world of fluorine chemistry. I'm always struck by how much work has taken place in that field, how long ago some of it was first done, and how many violently hideous compounds have been carefully studied. Here's how the experimental prep of today's fragrant breath of spring starts:The heater was warmed to approximately 700C.

  • 2 months ago | seekingalpha.com | Derek Lowe

    SummaryI was looking forward to seeing how Beam Therapeutics would do in their clinical trials of single-base DNA editing therapies, and this morning we have a readout. It was a very small trial: three patients each got 15mg, 30mg, or 60mg of BEAM-302 in a single infusion. Things look good in these early readouts, I have to say. It is of course a small number of patients, but the data make sense, and the numbers clearly seem to be going in the right direction.

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