Dianne Lumaquin-Yin

Jun 2, 2023 | nature.com | Eleanor M. Johns |Lorenz Studer |Dianne Lumaquin-Yin

AbstractMelanoma exhibits numerous transcriptional cell states including neural crest-like cells as well as pigmented melanocytic cells. How these different cell states relate to distinct tumorigenic phenotypes remains unclear. Here, we use a zebrafish melanoma model to identify a transcriptional program linking the melanocytic cell state to a dependence on lipid droplets, the specialized organelle responsible for lipid storage.