Ding XIONG

Feb 21, 2024 | biorxiv.org | Linghai Kong |Fang Yuan |Zijun Sun |Ding XIONG

AbstractMitochondrial plasticity, coordinated by fission and fusion, is crucial to ensure cellular functions. Mitochondrial fission is mediated by the GTPase Drp1 at the constriction site, which is proposed to be driven by the actin-myosin contractile force. However, the mechanism that propels constriction remains unclear, and the potential involvement of additional mechanisms in this process remains an open question.