Doan C. Nguyen

Sep 27, 2024 | nature.com | Doan C. Nguyen |Natalie Haddad |Pedro A Lamothe |Ignacio Sanz

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines are effective at protecting from severe disease, but the protective antibodies wane rapidly even though SARS-CoV-2-specific plasma cells can be found in the bone marrow (BM).

Feb 12, 2024 | nature.com | Doan C. Nguyen |Matthew Woodruff |Ignacio Sanz

AbstractFollowing infection or vaccination, early-minted antibody secreting cells (ASC) or plasmablasts appear in circulation transiently, and a small fraction migrates to the spleen or bone marrow (BM) to mature into long-lived plasma cells (LLPC). While LLPC, by definition, are quiescent or non-dividing, the majority of blood ASC are thought to be “blasting” or proliferative.