Donatella De Feo

Sep 22, 2024 | biorxiv.org | Juan Villar-Vesga |Donatella De Feo |Pauline Clément |Florian Ingelfinger

AbstractMultiple sclerosis (MS) is characterized by neuroinflammation, oxidative stress, iron toxicity and mitochondrial dysfunction. Reactive oxygen species (ROS) produced by mononuclear phagocytes (MPs) are widely held to drive tissue damage, yet the specific roles of central nervous system (CNS)- resident versus CNS-invading MPs remain unclear.