Dongbing Liu

Nov 3, 2024 | nature.com | Dongbing Liu |Hui cao |Kui Wu

AbstractGastrointestinal stromal tumor (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. We comprehensively describe the genomic and transcriptomic landscape of a cohort of 117 GISTs including 31 low-risk, 18 intermediate-risk, 29 high-risk, 34 metastatic and 5 neoadjuvant GISTs from 105 patients. GISTs have notably low tumor mutation burden but widespread copy number variations.

Dec 29, 2023 | nature.com | Hui Wan |Xianhuo Wang |Dongbing Liu |Xiaofei Ye |Gunilla Enblad |Rose-Marie Amini | +3 more

AbstractDespite the improvements in clinical outcomes for DLBCL, a significant proportion of patients still face challenges with refractory/relapsed (R/R) disease after receiving first-line R-CHOP treatment. To further elucidate the underlying mechanism of R/R disease and to develop methods for identifying patients at risk of early disease progression, we integrated clinical, genetic and transcriptomic data derived from 2805 R-CHOP-treated patients from seven independent cohorts.