Donglu Zhang

Aug 8, 2023 | mdpi.com | Ponien Kou |Elizabeth Levy |An Nguyen |Donglu Zhang

3. Results and DiscussionTwo PROTAC compounds, GNE-01 and GNE-02, with similar physicochemical properties, as shown in , were investigated. Both compounds are highly lipophilic molecules with very limited water solubility (<1 µM). Development of I.V. formulations for compounds with low water solubility can be challenging and cyclodextrins have been used as solubilizers in pharmaceutical technology to enhance solubility of both oral and I.V. formulations.