Donna Niedzwiecki

Apr 1, 2024 | nature.com | Russell Littman |Donna Niedzwiecki |Heinz-Josef Lenz |Myrl G. Marmarelis |Jose-Luis Ambite

AbstractUnlocking the full dimensionality of single-cell RNA sequencing data (scRNAseq) is the next frontier to a richer, fuller understanding of cell biology. We introduce q-diffusion, a framework for capturing the coexpression structure of an entire library of genes, improving on state-of-the-art analysis tools. The method is demonstrated via three case studies.

Apr 1, 2024 | flipboard.com | Myrl G. Marmarelis |Russell Littman |Francesca Battaglin |Donna Niedzwiecki |Alan Venook |Jose-Luis Ambite | +3 more

q-Diffusion leverages the full dimensionality of gene coexpression in single-cell transcriptomicsUnlocking the full dimensionality of single-cell RNA sequencing data (scRNAseq) is the next frontier to a richer, fuller understanding of cell …

Mar 8, 2024 | brnw.ch | Francesca Battaglin |Howard S Hochster |Donna Niedzwiecki |Richard Goldberg

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Mar 6, 2023 | bjsm.bmj.com | Justin Brown |Chao Ma |Qian Shi |Donna Niedzwiecki

MethodStudy designThe Cancer and Leukemia Group B (now part of the Alliance for Clinical Trials in Oncology) and Southwest Oncology Group (SWOG) trial 80 702 was a phase III double-blinded randomised study that used a 2×2 factorial design to test the primary hypothesis of the superiority of celecoxib compared with placebo and the secondary hypothesis of the non-inferiority of 3 months compared with 6 months of chemotherapy.