Dorota Androscuk

Dec 8, 2023 | biorxiv.org | Philip Earl Steele |David Frew |Kevin McLean |Dorota Androscuk

AbstractPrevious vaccination trials have demonstrated that thiol proteins affinity purified from Ostertagia ostertagi excretory-secretory products (O. ostertagi ES-thiol) are protective against homologous challenge. Here we have shown that protection induced by this vaccine was consistent across four independent vaccine-challenge experiments. Protection is associated with reduced cumulative faecal egg counts across the duration of the trials, relative to control animals.