Doug Barrick

1 month ago | pubs.acs.org | Mark Petersen |Soumya Prakash Behera |Ananya Majumdar |Doug Barrick

B: Biophysical and Biochemical Systems and ProcessesMay 5, 2025Mark PetersenThe T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United StatesSoumya Prakash BeheraThe T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N.

1 month ago | dx.doi.org | Mark Petersen |Ananya Majumdar |Doug Barrick |Soumya Prakash Behera

B: Biophysical and Biochemical Systems and ProcessesMay 5, 2025Mark PetersenThe T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United StatesSoumya Prakash BeheraThe T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N.

Jan 14, 2025 | biorxiv.org | Matt Sternke |Katherine W. Tripp |Doug Barrick |Johns Hopkins

AbstractThe biases revealed in protein sequence alignments have been shown to provide information related to protein structure, stability, and function. For example, sequence biases at individual positions can be used to design consensus proteins that are often more stable than naturally occurring counterparts. Likewise, correlations between pairs of residue can be used to predict protein structures.