Duane Currier

Nov 12, 2023 | nature.com | Hyeong-Min Lee |Min Pan |Duane Currier |Richard H. Chapple |Xueying Liu |Jacob Steele | +6 more

AbstractCombination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process, we conduct large-scale targeted CRISPR knockout screens in drug-treated cells, creating a genetic map of druggable genes that sensitize cells to commonly used chemotherapeutics.