Duncan Palmer

Jul 3, 2024 | nature.com | Caitlin Carey |Robbee Wedow |Duncan Palmer |Masahiro Kanai |Konrad J Karczewski |Samuel Bryant | +6 more

AbstractData within biobanks capture broad yet detailed indices of human variation, but biobank-wide insights can be difficult to extract due to complexity and scale. Here, using large-scale factor analysis, we distill hundreds of variables (diagnoses, assessments and survey items) into 35 latent constructs, using data from unrelated individuals with predominantly estimated European genetic ancestry in UK Biobank.

Mar 30, 2023 | science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Duncan Palmer

Dominance in the BiobankAccording to classical genetics, traits are usually divided into dominant and recessive, with all-or-none phenotypes. Such binary traits are often observed in plant and animal breeding, but they are rarely seen in human studies outside of monogenic disorders with Mendelian inheritance patterns. Instead, many traits included in human genomic studies exhibit additive effects based on gene dosage. Palmer et al.