Eduard Neu

3 weeks ago | nature.com | Sandra Zakrzewska |Samantha Nixon |Zhou Chen |Elizabeth Park |John V. Mulcahy |Eduard Neu | +2 more

AbstractDinoflagellates and cyanobacteria produce saxitoxin (STX) and ~50 congeners that disrupt bioelectrical signals by blocking voltage-gated sodium channels (NaVs). Consuming seafood carrying these toxins causes paralytic shellfish poisoning (PSP). Although NaVs and anuran STX binding proteins (saxiphilins, Sxphs) use convergent STX binding modes, the structural basis for STX congener recognition is unknown.