Eduardo A Maury

Oct 10, 2024 | science.org | Dimitri Fabrèges |Stephanie Hampton |Eduardo A Maury |Attila Jones

Editor’s summarySomatic mutations during brain development have been associated with several neurological disorders. Maury et al. performed deep whole-genome sequencing in dorsolateral prefrontal cortex tissue from donors with a diagnosis of schizophrenia (SZ), identifying somatic mutations inferred to have occurred before the end of neurogenesis (see the Perspective by An and Kim).

Dec 21, 2023 | science.org | Eduardo A Maury |Christopher Walsh |Kristopher T. Kahle

PerspectiveNeurologySurgical innovation is helping to identify roles for somatic mutations in brain disordersEduardo A. Maury, Christopher A. Walsh [email protected], and Kristopher T. Kahle [email protected] Info & AffiliationsScience21 Dec 2023Vol 382, Issue 6677pp. 1360-1362Somatic variants are genomic alterations present in some cells of the body but not in others.

Dec 21, 2023 | sciencemag.org | Guillaume Chomicki |Bana Jabri |Hojun Lee |Eduardo A Maury

PerspectiveNeurologySurgical innovation is helping to identify roles for somatic mutations in brain disordersSomatic variants are genomic alterations present in some cells of the body but not in others. In contrast to inherited germline variants, somatic variants are typically acquired during postzygotic cell divisions or from environmental factors.