Eduardo D Sontag

Nov 25, 2024 | biorxiv.org | Ankit Gupta |Eduardo D Sontag

AbstractThis paper introduces the notion of cumulative dose response (cDR). The cDR is the area under the plot of a response variable, an integral taken over a fixed time interval and seen as a function of an input parameter. This work was motivated by the accumulation of cytokines resulting from T cell stimulation, where a non-monotonic cDR has been observed experimentally. However, the notion is of general applicability.