Edward Yakubovich

Dec 29, 2023 | mdpi.com | Jonathan J. Hodgins |Edward Yakubovich |Barbara C. Vanderhyden |John Abou-Hamad

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Dec 11, 2023 | nature.com | Edward Yakubovich

AbstractCancer cells often metastasize by undergoing an epithelial-mesenchymal transition (EMT). Although abundance of CD8+ T-cells in the tumor microenvironment correlates with improved survival, mesenchymal cancer cells acquire greater resistance to antitumor immunity in some cancers. We hypothesized the EMT modulates the immune response to ovarian cancer. Here we show that cancer cells from infiltrated/inflamed tumors possess more mesenchymal cells, than excluded and desert tumors.