Eileen H. Shinn

Jun 28, 2024 | nature.com | Eileen H. Shinn |Kelly Hunt |Steven Lin

Correction to: Communications Medicine https://doi.org/10.1038/s43856-024-00514-x, published online 25 May 2024 In the original version of this article, there was an error in the Results and discussion section, which read ‘Using a cutoff of 70 (3.5 ASC/µl), the post-wash sEV counts for all CPP samples (N = 205) were above this threshold except for one sample, and for HDP samples (N = 106), all but three were above this cutoff, giving a cancer detection sensitivity of 99.5% and specificity of...

May 25, 2024 | nature.com | Eileen H. Shinn |Kelly Hunt |Steven Lin

AbstractSmall extracellular vesicle (sEV) analysis can potentially improve cancer detection and diagnostics. However, this potential has been constrained by insufficient sensitivity, dynamic range, and the need for complex labeling. In this study, we demonstrate the combination of PANORAMA and fluorescence imaging for single sEV analysis.

Mar 11, 2024 | onlinelibrary.wiley.com | Karen Smith |Carolyn Mead-Harvey |Gina Mazza |Eileen H. Shinn

1 INTRODUCTION Clinical trials have led to advances in treatment for breast cancer that have improved survival.1, 2 Guidelines endorse participation in a clinical trial as the preferred treatment for patients with breast cancer whenever possible.3 However, fewer than 10% of adult cancer patients enroll in a clinical trial.4, 5 Longstanding recognized barriers to participation include narrow access based on strict eligibility criteria; the geographic concentration of trials at academic...