Ekansh Mittal

St. Louis

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Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice - Nature Microbiology

Sep 5, 2024 | nature.com | Ekansh Mittal |Andrew Olive

AbstractMycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have distinct abilities to restrict Mtb. What enables Mtb survival in certain macrophage populations is not well understood. Here we used transposon sequencing analysis of Mtb in wild-type and autophagy-deficient mouse macrophages lacking ATG5 or ATG7, and found that Mtb genes involved in phthiocerol dimycocerosate (PDIM) virulence lipid synthesis confer resistance to autophagy.

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