Ekram Towsif

Apr 15, 2024 | biorxiv.org | Ekram Towsif |Blake Miller |Heidi Ulrichs |Shashank Shekhar

AbstractIntracellular actin networks assemble through the addition of ATP actin subunits at the growing barbed ends of actin filaments. This is followed by aging of the filament via ATP hydrolysis and subsequent phosphate release. Aged ADP–actin subunits thus treadmill through the filament before being released back into the cytoplasmic monomer pool as a result of depolymerization at filament pointed ends.

Dec 1, 2023 | biorxiv.org | Ekram Towsif |Shashank Shekhar

AbstractCellular actin networks display distinct assembly and disassembly dynamics resulting from multicomponent reactions occurring primarily at the two ends and the sides of actin filaments. While barbed ends are considered the hotspot of actin assembly, disassembly is thought to primarily occur via reactions on filament sides and pointed ends. Cyclase-associated protein (CAP) has emerged as the main protagonist of actin disassembly and remodeling.

Aug 28, 2023 | link.aps.org | Sergei Urazhdin |Ekram Towsif |Alexander Mitrofanov

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