Elba C Lira

Nov 22, 2023 | biorxiv.org | Ferdinand Althammer |Ranjan Roy |Matthew Kirchner |Elba C Lira

AbstractAbstractAimsHeart failure (HF) patients often suffer from cognitive decline, depression, and mood impairments, but the molecular signals and brain circuits underlying these effects remain elusive. The hypothalamic neuropeptide oxytocin (OT) is critically involved in the regulation of mood, and OTergic signaling in the central amygdala (CeA) is a key mechanism controlling emotional responses including anxiety-like behaviors.