Eleni P. Mimitou

May 8, 2024 | nature.com | Franco Izzo |Robert Myers |Levan Mekerishvili |Elliot Eton |Eleni P. Mimitou |Daniel Choi | +6 more

AbstractIn somatic tissue differentiation, chromatin accessibility changes govern priming and precursor commitment towards cellular fates1,2,3. Therefore, somatic mutations are likely to alter chromatin accessibility patterns, as they disrupt differentiation topologies leading to abnormal clonal outgrowth. However, defining the impact of somatic mutations on the epigenome in human samples is challenging due to admixed mutated and wild-type cells.

Apr 18, 2024 | biorxiv.org | Pei-Ching Huang |Eleni P. Mimitou |Keun P. Kim |Soogil Hong

AbstractDNA double-strand breaks (DSBs) are nucleolytically processed to generate single-stranded DNA tails for homologous recombination. In Saccharomyces cerevisiae meiosis, this 5'-to-3' resection involves initial nicking by the Mre11-Rad50-Xrs2 complex (MRX) plus Sae2, then exonucleolytic digestion by Exo1. Chromatin remodeling adjacent to meiotic DSBs is thought to be necessary for resection, but the relevant remodeling activity was unknown.