Elias Rosen

Oct 9, 2024 | ascpt.onlinelibrary.wiley.com | Austin Jones |Outcomes Science |Elias Rosen |Kara M. Rademeyer

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Despite the effectiveness of combination antiretroviral therapy in suppressing HIV peripherally, neuroHIV remains a challenge. Concurrent opioid use exacerbates neuroHIV by increasing neuroinflammation, neuronal injury, cognitive deficits, and altering antiretroviral concentrations in the brain. The interactions between HIV proteins, like Tat, opioids, and antiretrovirals significantly impact drug distribution and effectiveness within the brain.