Eliza Barkan

3 weeks ago | biorxiv.org | Madeleine Duran |Eliza Barkan |Amy Tresenrider |Heidi Lee

AbstractImprovements in single-cell sequencing protocols have democratized their use for phenotyping at organism-scale and molecular resolution, but interpreting such experiments poses computational challenges. Identifying the genes and cell types directly impacted by genetic, chemical, or environmental perturbations requires explicit modeling of lineage relationships amongst many cell types, over time, from datasets with millions of cells collected from thousands of specimens.