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1 month ago | 
thetransmitter.org | Sydney Wyatt |Caitlin James |Elizabeth Repasky |Sandra Sexton
A new photometry technique can track absolute levels of dopamine and monitor both fast and slow changes in its concentration in freely moving mice, according to a preprint posted on bioRxiv in January.
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2 months ago | 
thetransmitter.org | Shaena Montanari |Caitlin James |Elizabeth Repasky |Sandra Sexton
Reporter The Transmitter Share this article: Tags: Methods, Alzheimer’s disease, Amyloid beta, Animal models, animal research, models, neurodegenerative disease Transgenic mice typically help to standardize disease research, but not in the case of a common model of familial Alzheimer’s disease: The amount of amyloid beta plaque in 5XFAD mice—so named for the five familial Alzheimer’s disease variants they carry—varies depending on how they are bred, according to a study published 20 January...
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Nov 11, 2024 | 
thetransmitter.org | Anthony M. Zador |Caitlin James |Elizabeth Repasky |Sandra Sexton
The field of NeuroAI encompasses two intertwined research programs: the use of artificial intelligence (AI) to model intelligent behavior, and the application of neuroscience insights to improve AI systems. The motivation for using neuroscience to improve AI is clear: If the ultimate goal is, in the words of AI pioneer Marvin Minsky, “to build machines that can perform any […] task that a human can do,” then the most natural strategy is to reverse-engineer the brain.
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Nov 11, 2024 | 
thetransmitter.org | Anthony M. Zador |Caitlin James |Elizabeth Repasky |Sandra Sexton
“NeuroAI,” a portmanteau of “neuroscience” and “AI” (artificial intelligence), is on the rise. Almost unheard of until about five years ago, it has now emerged as a “hot” area of research—and the subject of a growing number of workshops, conferences and academic programs, including a BRAIN-Initiative-sponsored workshop that starts tomorrow. The intertwining of these disciplines was almost inevitable.
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Nov 6, 2024 | 
thetransmitter.org | Angie Voyles Askham |Jill Adams |Caitlin James |Elizabeth Repasky
Engrams, the physical circuits of individual memories, consist of more than just neurons, according to a new study published today in Nature. Astrocytes, too, shape how some memories are stored and retrieved, the work shows. The results represent “a fundamental change” in how the neuroscience field should think about indexing memories, says lead researcher Benjamin Deneen, professor of neurosurgery at Baylor College of Medicine.
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Nov 5, 2024 | 
thetransmitter.org | Jill Adams |Elizabeth Repasky |Sandra Sexton |Ashley Juavinett
A suicide-risk screening tool modified for use in autistic people compares well with clinician-based assessments. Spectrum previously covered a different questionnaire to assess suicidal thoughts and behaviors in people on the spectrum. AutismMice missing the FMR1 gene, a model of fragile X syndrome, show autism-like behaviors and disruptions in neural connections between the hippocampus and the prefrontal cortex, according to a preprint.
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Nov 4, 2024 | 
thetransmitter.org | Elizabeth Repasky |Sandra Sexton |Jill Adams |Ashley Juavinett
Sandra Sexton is associate professor of oncology and facility director and attending veterinarian at the Comparative Oncology Shared Resource (COSR) at the Roswell Park Comprehensive Cancer Center. She earned a doctorate in veterinary medicine in 1991 from the University of Agricultural Sciences in Bogotá, Colombia.
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Nov 4, 2024 | 
thetransmitter.org | Elizabeth Repasky |Sandra Sexton |Jill Adams |Ashley Juavinett
Professor of immunology Roswell Park Comprehensive Cancer Center Elizabeth Repasky is Lawrence J. Minet Professor of Immunology and program leader for the Cancer Stress Biology Program at Roswell Park Comprehensive Cancer Center. She graduated from Seton Hill University with a B.A. in biology, received her Ph.D. from the Buffalo State University and did a postdoctoral fellowship at the California Institute of Technology.
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Oct 28, 2024 | 
thetransmitter.org | Caitlin James |Elizabeth Repasky |Sandra Sexton |Shaena Montanari
Caitlin James is a Ph.D. candidate at Roswell Park Comprehensive Cancer Center in Buffalo, New York. After earning her B.S. in Biology at the University of Pittsburgh at Bradford, she began her thesis work at Roswell, which aims to identify molecular mechanisms by which chronic beta-adrenergic signaling impairs CD8 T-cell CD28 co-stimulatory signaling. She also studies how housing temperatures affect laboratory mouse T-cell biology. James is a National Cancer Institute Ruth L.
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Jun 15, 2023 | 00100-4&sz=64)
cell.com | Cameron MacDonald |Elizabeth Repasky
HighlightsMonitoring changes in the symptom of impaired thermal comfort (e.g., feeling cold) can be an important non-invasive measure of changes in the metabolic state of patients and preclinical animal models. Perception of thermal comfort can be altered by pathological and pharmacological changes. Chronic thermal discomfort is associated with significant immune suppression in murine models.
