Ellie StClair

Oct 29, 2024 | biorxiv.org | Junxiang Yin |Michael Wu |Jennifer White |Ellie StClair

AbstractBackground: Futile recanalization affects more than half of acute ischemic stroke (AIS) patients. Neutrophil extracellular traps (NETs) are a major factor of microvascular hypoperfusion after stroke. Deoxyribonuclease I (DNase) targeting NETs exhibited a neuroprotective effect in young mice with AIS. This study explored a novel direct intra-arterial administration of DNase therapy and its effect in aged mice with AIS.