Emily Wagner

Dec 5, 2024 | biorxiv.org | Emily Wagner |Martina Marras |Shashi Kant Kumar |Jacob Kelley

AbstractThe cardiac voltage-gated sodium channel, Nav1.5 initiates the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The functional Nav1.5 core consists of four homologous repeats (I, II, III, and IV), each formed from a voltage sensing and a pore domain. The channel also contains three cytoplasmic linkers (I-II, II-III, and III-IV).