Emma Sparr

Sep 20, 2023 | jbc.org | Rebecca Frankel |Emma Sparr |Sara Linse

AbstractThe double nucleation mechanism of amyloid β (Aβ) peptide aggregation is retained from buffer to cerebrospinal fluid (CSF), but with reduced rate of all microscopic processes. Here we used a bottom-up approach to identify retarding factors in CSF. We investigated the Aβ42 fibril formation as a function of time in the absence and presence of ApoA-I, recombinant high-density lipoprotein (rHDL) particles, or lipid vesicles.