Enrique B. Matias

Apr 21, 2024 | onlinelibrary.wiley.com | Jingyao Deng |David Cohen |Lucas Olson |Enrique B. Matias

1 INTRODUCTION Bone is a dynamic tissue that can respond and adapt to mechanical signals via collaboration between bone formation and bone resorption during bone remodeling events.1, 2 Skeletal unloading caused by prolonged bed rest,3 localized stress shielding after arthroplasty,4 cast immobilization,5 or space flight6 has been reported to cause muscle atrophy and bone loss.