Eoin D O’Sullivan

Nov 13, 2024 | nature.com | Christos Kiourtis |Maria Terradas-Terradas |Stephanie May |Anastasia Georgakopoulou |Amy Collins |Eoin D O’Sullivan | +14 more

AbstractCellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood.

May 31, 2023 | science.org | Eoin D O’Sullivan

AbstractProgressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1+) cells are a major source of activated fibroblasts in multiple organs, but the links between injury, inflammation, and Gli1+ cell expansion and tissue fibrosis remain incompletely understood.