Erika Darrah

Mar 20, 2023 | nature.com | Eduardo Gomez-Banuelos |Daniel Goldman |Erika Darrah |Michelle Petri |Yikai Yu |Cheryl A. Sherman-Baust | +1 more

AbstractAnti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and antigenic properties. Unexpectedly, during the clinical and molecular characterization of autoantibodies to the endonuclease DNase1L3 in patients with systemic lupus erythematosus (SLE), we identified a subset of neutralizing anti-DNase1L3 antibodies previously catalogued as anti-dsDNA. Based on their variable heavy-chain (VH) gene usage, these antibodies can be divided in two groups.