Eva Nogales

Sep 19, 2024 | cell.com | Los Alamos |Eva Nogales |Simon Poepsel

Keywordsepigeneticschromatincryo-EMgene regulationdevelopmenttrans-activationPRC2histone methyltransferaseIntroductionPolycomb repressive complex 2 (PRC2) is an essential chromatin regulator that harbors histone methyltransferase (HMTase) activity mediated by its catalytic subunit enhancer of zeste homolog 2 (EZH2).

May 30, 2024 | nature.com | Eva Nogales

Macromolecules are involved in myriads of interactions that regulate their cellular function. While years of structural biology progress was built by reducing this complexity, a molecular understanding of biological processes requires the characterization of ever larger and more dynamic molecular assemblies. Cryo-electron microscopy is rising to this challenge.

Sep 13, 2023 | onlinelibrary.wiley.com | Eva Nogales |Elizabeth Kellogg

Microtubules (MTs) are ubiquitous cytoskeletal elements of eukaryotic cells that play a myriad of roles, all of them involving a number of microtubule-associated proteins (MAPs) that recognize, bind, and often regulate MT activity. Polymers of repeating αβ-tubulin subunits, MTs are made of protofilaments that associate in parallel and a staggered manner to give rise to a pseudo-helical array of tubulin dimers.