Evan D. Kharasch

Mar 11, 2024 | dmd.aspetjournals.org | Evan D. Kharasch |Eric J. Lenze

AbstractBupropion is used for treating depression, obesity, seasonal affective disorder, and for smoking cessation. Bupropion is commonly-prescribed, but has complex pharmacokinetics and interindividual variability in metabolism and bioactivation may influence therapeutic response, tolerability and safety. Bupropion is extensively and stereoselectively metabolized, the metabolites are pharmacologically active, and allelic variation in CYP2B6 affects clinical hydroxylation of single-dose bupropion.