Ezimamaka Ajufo

Dec 1, 2023 | jacc.org | Ezimamaka Ajufo |Krishna G. Aragam

IntroductionIdentifying individuals at high risk for coronary artery disease (CAD) remains a public health priority; however, current clinical risk prediction tools often fall short. Polygenic scores—a byproduct of the Human Genome Project and corresponding advancements in the efficient analysis of large genomic data—are quantitative factors that capture an individual’s inherited predisposition to a particular trait.