Falak Pahwa

Feb 9, 2024 | biorxiv.org | Falak Pahwa |Shweta Chaudhary |Ranjan Nanda |Anushka Dayal

AbstractMycobacterium tuberculosis (Mtb), through aerosol, reaches the lungs to cause pulmonary tuberculosis (TB); however, it may also affect the metabolism of other tissues in age-specific ways. In this study, female C57BL/6 mice (2 and 5 months old; M) were infected with a low aerosol dose (100-200 cfu) of Mtb H37Rv to monitor tissue mycobacterial load and multi-tissue metabolite profiling using gas chromatography and mass spectrometry (GC-MS).

Aug 24, 2023 | biorxiv.org | Falak Pahwa |Shweta Chaudhary |Shivam Chaturvedi |Ranjan Nanda

AbstractAgeing increases susceptibility to infectious diseases like tuberculosis (TB), however limited reports are available on the cellular and molecular details in aged (>60 years) patients. In this study, we asked how low aerosol dose of Mycobacterium tuberculosis H37Rv (Mtb) affects aged (17/19 months; M) C57BL/6 mice in their bacterial clearance, liver micronutrient levels, circulatory cytokines and T cell distribution compared to younger (2/4M) controls.