FAN Jianchun

Mar 4, 2024 | zgsydw.cnjournals.com | WU Xueliang |FAN Jianchun |Zhang Qi |GUO Fei

摘要:肿瘤相关巨噬细胞(TAMs)是肿瘤免疫微环境(TIME)中的优势细胞群,是TIME 中免疫系统抑制和肿瘤细胞增殖最重要的调节细胞。Src 同源2 蛋白酪氨酸磷酸酶2(SHP-2)是一种非受体蛋白酪氨酸磷酸酶,该磷酸酶在从细胞表面到细胞核的信号传递中发挥重要作用,且是介导细胞增殖和分化的关键细胞内调节因子,参与多种生长因子和细胞因子的信号通路。最近的研究表明,SHP-2 是决定TAMs 功能的一个关键酶,但是由于其功能多变,在不同的实体瘤微环境中发挥不同甚至是相反的作用。基于此,本文综述了SHP-2 在TAMs 功能及在相关实体瘤中的作用,为肿瘤的免疫和靶向治疗提供坚实的科学依据。

Aug 2, 2023 | zgsydw.cnjournals.com | FAN Jianchun

At present, malignant tumors are one of the most important diseases that threaten human health, and related disability and fatality rates are increasing yearly. Protein disulfide isomerase A3 (PDIA3), an important member of the PDI family, is a type of mercaptan oxidoreductase with a wide range of functions. Its increased expression in a variety of tumors is closely related to the invasion and metastasis of tumor cells.