Farhad Shakeri

1 month ago | nature.com | Dominik Kaczmarek |Nils P. Sommer |Michael Hölzel |Farhad Shakeri |Matthias Becker |Marc Beyer | +11 more

AbstractFamilial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, duodenal phenotypes vary, indicating that additional factors, such as the local immune system, play a role. We observe an increase in duodenal IL-17A(+)NKp44(−) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched in adenomas and carcinomas.