Fengjiang Liu

Jul 3, 2024 | nature.com | Ting Ran |Luke W. Guddat |Yan Gao |Fengjiang Liu

AbstractBedaquiline (BDQ), a first-in-class diarylquinoline anti-tuberculosis drug, and its analogue, TBAJ-587, prevent the growth and proliferation of Mycobacterium tuberculosis by inhibiting ATP synthase1,2. However, BDQ also inhibits human ATP synthase3. At present, how these compounds interact with either M. tuberculosis ATP synthase or human ATP synthase is unclear. Here we present cryogenic electron microscopy structures of M.

May 14, 2024 | link.aps.org | Fengjiang Liu |Kai Chen |Wei Yan

Fengjiang Liu1,2,*, Kai Chen3,4,5,*, Wei Yan1,2, Weiwei Tang1,2, Hao Zhang3,4,6, Richard J.