Fernando Luis Noguera-Cañas

2 months ago | biorxiv.org | José Gavira |Jose Paredes |José Paredes |Fernando Luis Noguera-Cañas |Aitor Díaz-Agustín

AbstractAtg18 —for Autophagy-related gene 18— is a member of the PROPPIN (β-propellers that bind polyphosphoinositides) family, which is known for its binding to phosphorylated phosphoinositides through two conserved binding sites. Although Atg18 binding to polyphosphoinositides is crucial for its roles in both autophagic and non-autophagic functions within cells, the precise molecular mechanism by which Atg18 selectively binds to specific phosphatidylinositols remains unresolved.