Fiona Lalloo

Jul 19, 2024 | jmg.bmj.com | Terri McVeigh |Fiona Lalloo |Kevin Monahan |Andrew Latchford

Carrier testing for partners of MUTYH variant carriers: UK Cancer Genetics Group recommendations Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

May 30, 2024 | jmg.bmj.com | Terri McVeigh |Fiona Lalloo |Kevin Monahan |Andrew Latchford

Delivery of Health CareDigestive System NeoplasmsDNA RepairGastroenterologyGenetic Carrier ScreeningMUTYH-associated polyposis (MAP) is an autosomal recessive condition caused by biallelic constitutional pathogenic variants in the MUTYH gene. MAP is associated with colonic polyposis (typically adenomas, but less commonly hyperplastic, serrated or mixed) and increased cancer (colorectal, duodenal and others) risk.

May 22, 2023 | jmg.bmj.com | Nicola Flaum |Emma J. Crosbie |Emma Woodward |Fiona Lalloo

Article The inherited landscape of epithelial ovarian cancer (EOC) is well established with contributions from homologous recombination deficiency (HRD) genes, particularly BRCA1 and BRCA2, and mismatch repair deficiency (MMRD) genes MSH2, MLH1, MSH6 and PMS2.1 High-grade serous ovarian cancer (HGSOC) is associated with HRD, accounting for up to 23% of HGSOC.2 Approximately 3% of EOC cases occur in <30 years of age, described as very young onset ovarian cancer (VYOC).1 The pathology in VYOC...

Mar 8, 2023 | jmg.bmj.com | Nicola Flaum |Emma J. Crosbie |Emma Woodward |Fiona Lalloo

Article The inherited landscape of epithelial ovarian cancer (EOC) is well established with contributions from homologous recombination deficiency (HRD) genes, particularly BRCA1 and BRCA2, and mismatch repair deficiency (MMRD) genes MSH2, MLH1, MSH6 and PMS2.1 High-grade serous ovarian cancer (HGSOC) is associated with HRD, accounting for up to 23% of HGSOC.2 Approximately 3% of EOC cases occur in <30 years of age, described as very young onset ovarian cancer (VYOC).1 The pathology in VYOC...