Florentina Vandiver

Oct 29, 2024 | biorxiv.org | James McGinnis |Florentina Vandiver |Xin Bai |Alberto Bremauntz Enriquez

AbstractPediatric malignancies frequently harbor chromosomal translocations that induce expression of fusion oncoproteins. The EWSR1-FLI1 fusion oncoprotein acts as a neomorphic transcription factor and is the dominant genetic driver of Ewing sarcoma. Interrogation of the mechanisms by which EWSR1-FLI1 drives tumorigenesis has been limited by a lack of model systems to precisely and selectively control its expression in patient-derived cell lines and xenografts.