Florian Perner

2 months ago | onlinelibrary.wiley.com | Florian Perner |Jayant Y. Gadrey |Scott Armstrong

1 ONCOGENIC KMT2A-COMPLEXES IN LEUKEMIA In mammalian cells six members of the Mixed-Lineage Leukemia (MLL)-family (MLL1/KMT2A, MLL2/KMT2B, MLL3/KMT2C, MLL4/KMT2D, SETD1A/KMT2F and SETD1B/KMT2G) encode for methyltransferases that catalyze Histone 3 lysine 4 mono-, di- and tri-methylation (H3K4me1/2/3) at promotors and enhancer regions and influence transcription.

Aug 21, 2023 | frontiersin.org | Naseema Gangat |Florian Perner |Valerio De Stefano

1 IntroductionMyeloproliferative neoplasms (MPN) are driven by specific mutations in one of the three genes – JAK2, MPL or CALR (1). These mutations cause uncontrolled activation of the JAK-STAT signaling pathway leading to the release of secondary mediators of pro-survival and proliferative nature (2).